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D-312empresa anónima / Estados Unidos
2843
Seeking: Solution for Heavy Metal and Toxin removal
heavy metal, toxin, removal
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Resultado deseado
We are seeking new technologies, methods or processes to enable the removal of heavy metals and toxins from waste streams in steel making. The waste produced during steel making contains many metal oxides and dioxins. The most toxic waste is when scrap is burned as this includes plastic, paint, etc.
21/12/11 - El deadline de esta demanda ha caducado
Compartir demanda Detalles de la demanda :
Potential Solution Areas
o Metal separation/extraction solutions - enable recovery and recycling of heavy metals. Especially iron oxide as this weighs most and separated out could lower transportation costs.
o Abatement/reduction of dioxins - precipitation
o Pelletizing dust on site - make less volatile, enable re-use in liquid slag and easier to transport
A solution that enables on-site management of the dust would be high value add.
Background:
Waste (Dust) constitutes a serious disposal problem for steel companies and it is of extreme interest to be able to address the costs of handling. Some companies do exist that can recover zinc, iron, lead, calcium and other minerals from the dust; however the remaining residual material must still be land filled in secure dump sites. The cost to transport and landfill due to its toxic nature is high. Furthermore, future legislation is expected to be more and more stringent, and may pose significant problems for steel producers.
Constraints:
Needs to be Cost Effective solution when compared to landfill - currently approx E60 per ton
Desired Outcome
Ability to treat dust cheaply so it becomes less reactive and non-toxic (removal of heavy metals). It would then cost less to landfill as it won't be classed as toxic waste, and it could be reused with slag or other application.
Previously Attempted Solutions
Currently nothing in the market on how best to treat dust on site, majority is shipped away for land fill.
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D-239empresa anónima / Reino Unido
1425
Orally delivered modified release drug delivery systems to overcome first-pass metabolism
Drug, Delivery, metabolism,
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Resultado deseado
A global OTC drug products group with offices in the UK is seeking orally delivered modified release drug delivery systems that extend the efficacy of active pharmaceutical ingredients (APIs), which are susceptible to a large first-pass metabolism.
27/08/10 - El deadline de esta demanda ha caducado
Compartir demanda Detalles de la demanda :
The choice of modified release dosage form for drugs is mainly determined by their physicochemical properties. In general, modified release systems are considered unsuitable for APIs which undergo extensive first-pass metabolism. The lack of technologies that fulfill the function of delivering such actives puts limitations on the ability to achieve further therapeutic benefits and consumer benefit for these classes of APIs.
Technical Requirements
The target is therefore to access orally delivered modified release drug delivery systems that extend the efficacy of certain APIs by avoiding and/or overcoming pre-systemic metabolism. Potential dosage forms include tablet, liquid, capsule, granules, etc. The release may occur in the gastrointestinal tract ranging from the oral cavity to the large intestine. There will be a requirement to potentially meet a variety of local and/or global regulatory requirements.
Additional Supporting Data Required:
Mandatory :
• A theoretically convincing principle that could enable extended efficacy over a certain period of time (12 hours or more), AND
• Preliminary data/models (not limited to dissolution test) that demonstrate proof of principle against APIs that face similar issues described above.
Preferred:
• In vivo data that demonstrates the proof of the principle against APIs described above.
Desirable:
• Compatibility with other drug delivery platforms.
The materials should also meet the following requirements for incorporation into a consumer product:
– Compatible with typical Health Care product packaging and storage
– Not require storage or handling under special or inert conditions, e.g. under nitrogen or under oil.
– Cost appropriate for consumer products (when incorporated at the required level). As examples, this means maximum £20/kg (GBP) for an ingredient incorporated at 1-5%, and maximum £250/kg (GBP) for an ingredient incorporated at <0.1%
– Technologies must be capable of withstanding any process stresses e.g. temperature without chemical degradation or any adverse effects
– Technology must not reduce the existing quality of the user’s experience e.g. poor taste, smell etc.
– Able to be incorporated into current products using simple batch mixing at room temperature and atmospheric pressure with minimal heating/cooling and no or minimal changes required to current clean-down processes.
– Not be harmful for human use (not classified or suspected to be a toxin, carcinogen, mutagen, irritating to the human respiratory system) with respect to the concentrations used in the final product. Not harmful to the environment (including not being a photo-reactive volatile organic compound).
– Ideally offer scope for patent protection with the desired application and format.
– Not negatively affecting the efficacy or aesthetics of the final product.
– Ingredients should be Reach supported
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D-237empresa anónima / Reino Unido 1097
OTC Transdermal and Transmucosal Delivery
transdermal, transmucosal, Drug, Delivery, OTC
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Resultado deseado
An international Pharma products group with offices in the UK is seeking technologies and approaches that enable the systemic delivery of common OTC medications for treating typical self-limiting illnesses including aches, incidental pain, colds and flu via transdermal and transmucosal routes, to provide at least 1 of the following benefits:
• Faster acting
• Longer lasting
• Lower dose of active ingredient(s) required
26/08/10 - El deadline de esta demanda ha caducado
Compartir demanda Detalles de la demanda :
Background
The majority of consumer products focused on the treatment and relief from common aches, incidental pain, colds and flu are delivered orally, which may result in reduced speed of action due to digestion and associated metabolic action, as well as being somewhat inconvenient and unpleasant to take.
Technologies and approaches are sought that enable treatments to be delivered to the consumer in a convenient and easy to use format, that also offer the potential benefits of being faster acting, lower dose and/or longer lasting.
Technical Requirements
Transdermal and transmucosal (buccal/sublingual) delivery present several challenges:
• Most active ingredients are large molecules, with some being acidic in nature and having poor water solubility
• It is necessary to be able to deliver 5-50mg of active within 15 minutes
• The active ingredient must permeate the skin into the bloodstream, without causing irritation
• Buccal/sublingual delivery mechanisms need to address potential taste issues, deal with a mucosal and salival environment and not get washed away
• The approach may require permeation ingredients to help the active reach the bloodstream, either paracellularly (to avoid lipid interference in the tissues) or through the cell membranes themselves.
The target is therefore to access technologies and approaches that can successfully deliver against these challenges, providing new or improved benefits vs. current approaches. Products already on the market for the treatment of common aches, incidental pain, colds and flu, or technologies that deliver topical or localised benefits only are not sought.
It would be advantageous to also demonstrate the following:
•In-vivo data that shows correlation with in-vitro studies – to demonstrate the action of the solution.
The materials should also meet the following requirements for incorporation into a consumer product:
1) Compatible with typical OTC Pharmaceutical product packaging and expected to be stable under global ambient temperature and humidity conditions for a period of 2 years.
2) Not require storage or handling under special or inert conditions, e.g. under nitrogen or under oil.
3) Soluble or readily dispersed in the formulations and not negatively affect or interfere with the properties of other components in the formulation.
4) Technologies must be capable of withstanding any process stresses e.g. temperature without chemical degradation or any adverse effects
5) Able to be able to be incorporated into current products using simple batch mixing at room temperature and atmospheric pressure with minimal heating/cooling and no or minimal changes required to current clean down processes.
6) Cost appropriate for consumer products (when incorporated at the required level). As examples, this means maximum £20/kg (GBP) for an ingredient incorporated at 1-5%, and maximum £250/kg (GBP) for an ingredient incorporated at <0.1%
7) Technology must not reduce the existing quality of the user’s experience e.g. poor taste, smell etc.
8) Not be harmful for human use (not classified or suspected to be a toxin, carcinogen, mutagen, irritating to the human respiratory system) with respect to the concentrations used in the final product. Not harmful to the environment (including not being a photo-reactive volatile organic compound).
9) Ideally offer scope for patent protection with the desired application and format.
10) Ingredients must meet the required pharmacopoeia or monograph (i.e. Ph.Eur, USP) and supported under REACh where applicable.
11) Must not appear on these restricted substance lists :
• OSPAR (http://www.ospar.org/v_substances/browse.asp?menu=00950304450072_000000_000000)
• DLUS(http://www.mst.dk/default.asp?Sub=http://www.mst.dk/udgiv/Publications/2000/87-7944-277-3/html/default _eng.htm)
• Proposition 65 (http://www.prop65news.com/pubs/brochure/madesimple.html).
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