Innovación en crystallization : Oportunidades ...

O-63Enantia / España 2035

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Tecnologías de co-cristalización y estudios en forma sólida para la investigación y desarrollo de ingredientes farmacéuticos activos.

Solubility, bioavailability, Cocrystals, Solid form screening, Solid form characterisation
- Descripción de la oferta tecnológica :
  
  La compañía ha desarrollado un importante know-how en cuanto a la adecuada identificación contra-iones / cofomers basados en la estructura molecular del compuesto diana. El criterio de selección permite a Enantia maximizar la eficacia en la detección, siendo capaz de ofrecer resultados positivos en un tiempo relativamente corto (en contraste con los métodos de alta a través de grandes conjuntos de datos que generan resultados menos estudiados con precisión y procesos mucho más largos).
  
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  Aspectos nuevos e innovadores
  
  CO-CRYSTALLlZATION TECHNOLOGIES
  
  The application of co-crystallization technologies has only recently been recognised as a way to improve physico-chemical properties of APIs and their synthetic intermediates. Better profiles may include enhanced solubility, better stability and the extension or widening of IP position with respect to the development of active pharmaceutical ingredients (APIs).
  
  Enantia has developed a strong know-how in terms of identifying suitable counter-ions/ cofomers based on the molecular structure of target compound. The oriented screening approach enables Enantia to maximize effectiveness in screening, being able to deliver positive results in relatively short time (in contrast with high throughout put methods where large sets of data are generated resulting in less accurately studied results and time consuming processes.)
  
  The solid forms department has as well experience in polymorphism screening and polymorphism study. By the use of co-crystal technology new polymorphs might be found even for the cases in which by classical techniques the number of polymorphs has been extensively studied.
  
  Enantia as well successfully applies co-crystallization technologies in key areas of process chemistry: i.e. purifications and resolutions. Co-crystals have been demonstrated to be complementary to salts for purification purposes, so products can be isolated using co-crystallization processes in order to obtain the desired specifications.
  
  For enantiomeric resolutions, co-crystals can be an excellent alternative to salts (in cases when the molecule is not ionisable or the resolution is not effective). With chiral co-formers enantiomeric resolutions have been achieved to maximum standards of enantiomeric purity.
  
  SOLID FORM STUDIES
  
  Enantia solid forms department offers services for the analysis and characterisation of solid forms.
  In house X-Ray Diffractometer: to obtain crystallographic data from solid samples.
  Single crystal Diffraction: to determine the crystalline structure of a single crystal sample.
  Synchrotron beam light: to determine crystalline structure from either single crystal to powder samples. High sensibility to determine very small quantities of different crystal forms in a sample.
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O-1080Enantia / España 895

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Cocristales para mejorar la solubilidad en sólidos

cocrystallisation, drug development, bioavailability, Cocrystals, API, APIs, active ingredients, pharmaceutical products, drug products, solubility enhancement, pharmaceutical, pharmaceutics, pharma, bioavailability
- Descripción de la oferta tecnológica :
  
  La solubilidad es uno de los parámetros que determinan la biodisponibilidad de un compuesto. Por lo tanto, es una preocupación importante en el desarrollo de fármacos, teniendo en cuenta que una gran porcentaje de los fármacos candidatos nunca llegan al mercado debido a problemas de solubilidad y que las tendencias recientes de descubrimiento tienden a compuestos más lipofílicos.
  
  En este contexto, las soluciones de preformulación para mejorar la solubilidad en agua tienen un papel clave que desempeñar.
  
  COCRYSTALLISATION ofrece una alternativa a la detección de sal cuando el enfoque de la sal es ineficaz o la molécula no tiene puntos ionizables. Un cocrystal podría mejorar el efecto de solubilidad por:
  
  - Mejorar la termodinámica
  - Mejora cinética: "efecto resorte y paracaídas"
  
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  Aspectos nuevos e innovadores
  
  The application of cocrystallization technologies has only recently been recognised as a way to improve physico-chemical properties of APIs and their synthetic intermediates. Better profiles may include enhanced solubility, better stability and the extension or widening of IP position with respect to the development of active pharmaceutical ingredients (APIs).
  
  Unlike salt formation, cocrystallization does not rely on ionisation of the API and the counterion to make a crystalline structure. Instead, both components utilise intermolecular interactions, such as hydrogen bonding, to combine and yield a uniform crystalline material. Combining an API with a pharmaceutically acceptable agent in this guest/host manner has become an increasingly attractive route for developing pharmaceutical products.
  
  For example, cocrystallization offers an alternative when salt screening is either unsuccessful or impossible (due to lack of ionisation sites) to improve the physical properties of a drug. Furthermore, exploring the co-crystallization potential around an API increases the intellectual property protection over a particular drug product, thus reducing the risk of costly litigation and market erosion. Leer más
O-833UATEC - Technology Transfer Office of University of Aveiro / Portugal 1813

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Composición de vidrios bioactivos, su uso y el método de obtención del mismo

Bioactive glass, glass-ceramics, biomedical application, bone cements
- Descripción de la oferta tecnológica :
  
  Un grupo de investigadores ha desarrollado vidrios bioactivos y "glass-ceramics" capaces de desarrollar una capa superficial de hidroxiapatita carbonatada después de una hora de inmersión en el fluido corporal simulado (SBF). La invención abarca una variada serie de materiales (andamios porosos, fibras y mallas, gránulos y polvos para la regeneración ósea y la ingeniería de tejidos, rellenos bioactivos como cementos óseos que se utilizan en ortopedia y odontología, y para el recubrimiento de los implantes metálicos).
  
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  The advantages of the materials and methods object of this invention, relatively to the state of the art solutions, include the easy processing of the powders in aqueous environment, the complete densification of the glass matrix up to 800ºC without devitrification, high flexural strength (~85 MPa), enhanced bioactivity and lower degradation rate in comparison to the 45S5 Bioglass ®. Leer más
O-1125University of Cádiz / España 671

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Nuevo proceso para el uso de bagazo de cerveza (granos cerveceros gastado) para obtener materias primas para la producción de biocombustibles

biofuels, biofuel, biodiesel, beer bagasse, beer bagasse, beer, brewers, breweries, brewing industry, agro-food, agroofood, biomass, bagasse, waste management, waste
- Descripción de la oferta tecnológica :
  
  El grupo de investigación en la UCA sobre "alelopatía en plantas superiores y microorganismos" (FQM-286) ha desarrollado un procedimiento de hidrólisis ácida, por lo que los materiales precursores de biocombustibles y otros productos de alto valor agregado se obtienen a partir de cereales o bagazo pasado, el principal producto de desecho de cervecerías . El contenido de este material en los lípidos y fibra alimentaria hace que sea un producto ideal para esta aplicación. El objetivo es hacer un uso económico de los subproductos de bajo valor de la industria cervezera, para la producción de bioetanol y biodiesel.
  
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  Currently, considerable quantities of lingo-cellulosic residues are generated continuously in many sectors of the agro-food industry. If these can be suitably processed, they are of great commercial interest to industry as potential raw materials for the production of biofuels and a variety of other high value-added products.
  
  The residual biomass of the agro-food industry typically has a high content in lipids, carbohydrates, proteins and other compounds of industrial interest. The only limitations to its use as a precursor of biofuel are the economic viability of the process for obtaining these precursors and their quality.
  
  One of the byproducts of special interest for this application is spent beer grain, also known as bagasse; given the existing lack of commercial value, this bagasse is widely available as a low-cost raw material. Currently, the principal application of bagasse is as feedstuff for livestock. In general, bagasse does not represent a source of income for breweries, and the reason why it is sold is to minimize the associated problems of waste management and disposal.
  
  The UCA research group on "Allelopathy in Higher Plants and Microorganisms" (FQM- 286) has developed an acid hydrolysis procedure whereby precursor materials for biofuels and other high -value-added products are obtained from beer bagasse. Its content in lipids and food fibre (equal to or more than 5% and 20%, dry weight, respectively), make it an ideal material for this application. This would represent a more attractive commercial outlet for many of the residues resulting from operations of the agro-food industry, and in particular, for beer bagasse.
  
  The object of the process is to obtain two different products. The first is an oil consisting mainly of the fats contained in the bagasse; the second is a substance rich in sugars or molasses. The oil is of interest as raw material for the production of biodiesel by the process of transesterification; the molasses can be employed as raw material for the production of bio-ethanol by means of fermentation. Molasses can also be formulated as sugar, after a crystallization process.
  
  The oil would be particularly useful for correcting the viscosity of biodiesel, thus achieving the optimum parameters for its use as biofuel.
  
  In outline, the process developed by the research group consists of a principal line, in which a series of operations take place for the conditioning of the bagasse, such as milling, extraction of lipids and the separation of the resulting solids. Downstream, this line divides into two secondary lines: in one line, for production of oils, the solvents from the prior extraction stage are separated out; in the other secondary line, for the production of molasses, an acid hydrolysis of the sugars is carried out.
  
  Another significant feature is that the optimum operating mode of the process is continuous operation, although batch loading is also accepted. Leer más

Innovación en crystallization : Oportunidades ... | Ofertas

Innovación en crystallization : Oportunidades ... | Ofertas

Solicitar información>> Compartir tecnología>> Tecnologías de co-cristalización y estudios en forma sólida para la investigación y desarrollo de ingredientes farmacéuticos activos.

Solubility, bioavailability, Cocrystals, Solid form screening, Solid form characterisation

Solicitar información>> Compartir tecnología>> Cocristales para mejorar la solubilidad en sólidos

cocrystallisation, drug development, bioavailability, Cocrystals, API, APIs, active ingredients, pharmaceutical products, drug products, solubility enhancement, pharmaceutical, pharmaceutics, pharma, bioavailability

Solicitar información>> Compartir tecnología>> Composición de vidrios bioactivos, su uso y el método de obtención del mismo

Bioactive glass, glass-ceramics, biomedical application, bone cements

Solicitar información>> Compartir tecnología>> Nuevo proceso para el uso de bagazo de cerveza (granos cerveceros gastado) para obtener materias primas para la producción de biocombustibles

biofuels, biofuel, biodiesel, beer bagasse, beer bagasse, beer, brewers, breweries, brewing industry, agro-food, agroofood, biomass, bagasse, waste management, waste

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Tecnologías de co-cristalización y estudios en forma sólida para la investigación y desarrollo de ingredientes farmacéuticos activos.

Solicitar información>> Compartir tecnología>>
Cocristales para mejorar la solubilidad en sólidos

Solicitar información>> Compartir tecnología>>
Composición de vidrios bioactivos, su uso y el método de obtención del mismo

Solicitar información>> Compartir tecnología>>
Nuevo proceso para el uso de bagazo de cerveza (granos cerveceros gastado) para obtener materias primas para la producción de biocombustibles