Innovación en nanoparticles : Oportunidades ...

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O-803University Pablo de Olavide / España 1687

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Nuevas nanopartículas metálicas funcionalizadas con moléculas orgánicas fluorescentes

metal, nanoparticles, fluorescent, Biomarkers, contaminants, Quantum Dots.
- Descripción de la oferta tecnológica :
  
  Esta invención hace referencia a nuevas nanopartículas metálicas funcionalizadas con moléculas orgánicas fluorescentes obtenidas de una manera sencilla, en una sola etapa, por la disolución de sales metálicas (plata, oro, aluminio, platino, cobalto y paladio) despues de su tratamiento en un medio acuoso con una agente reductor en presencia de una molécula orgánica fluorescente. Se pueden utilizar en los ensayos de detección que emplean técnicas de fluorescencia, y es interesante debido a que posee las ventajas de las nanopartículas de metal y de los puntos cuánticos.
  
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  • In these nanoparticles, the fluorophore is not deactivated by the proximity of metals. The proximity of the fluorophore leads to increase both the intensity of the fluorophore emission and its stability, a feature that makes them a good alternative to the use of "conventional" organic fluorophores.
  
  • They are stable in a water medium, capable of functionalisation with other molecules of interest (such as antibodies in biomedical applications) and they are biocompatible.
  
  • In addition to the well-known fluorescence techniques, these nanoparticles can also (and will preferably) be detected by means of other techniques, specifically UV-Vis, IR and Raman.
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O-1046University Pablo de Olavide / España 826

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Procedimiento para la obtención de nanopartículas de metal y su uso en la espectroscopia de Raman

metal nanoparticles, nanoparticles, raman spectroscopy, spectroscopy, sensors, Organic compounds, organic contaminants, pesticides, agricultural, agriculture, phytosanitary, Water
- Descripción de la oferta tecnológica :
  
  La presente innovación se refiere a un procedimiento para la obtención de nanopartículas de metales a partir de soluciones de sal utilizando sus cationes metálicos, tales como sales de plata, oro, cobre, aluminio y paladio, para su uso en la fabricación de sensores para la detección de compuestos orgánicos del calibre de pesticidas, por medio de la espectroscopia de Raman.
  
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  - The procedure described in this invention allows metal nanoparticles to be obtained that can be laid on substrates and, particularly, silver, gold, copper, aluminium or palladium nanoparticles with morphologies that make them especially useful for the manufacture of sensors applicable to the detection of organic compounds (in crops, water, food) by means of the "Surface-Enhanced Raman Spectrometry”.
  - The method of reference for the detection of organic contaminants is chromatography coupled with high resolution mass spectrometry. This method has drawbacks, solved in this patent, such as the high cost of the instruments required and the labour-intensive preparation of the samples. -
  When the compound to be detected is adsorbed on an adequate nanostructured substrate, trace amounts of the compound can be detected by “Surface-Enhanced Raman Spectroscopy”.
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O-935Institute of Chemical Research of Catalonia (ICIQ) / España 717

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Nuevo soporte de nanopartículas de rutenio como catalizadores altamente eficientes para la hidrogenación de compuestos aromáticos: en busca de licencia y / o socio de desarrollo conjunto

ruthenium nanoparticles, catalysts, hydrogenation of aromatics, fragrances, flavors, benzene hydrogenation, hydrogenation of phthalates, aromatics
- Descripción de la oferta tecnológica :
  
  Hemos desarrollado un catalizador heterogéneo altamente activo y estable que consiste en nanopartículas de rutenio estabilizadas con ligandos de fosfina incrustados en un soporte sólido. Este catalizador es estable en aire, fácil de preparar, y es muy activo en la reacción de hidrogenación de compuestos aromáticos en condiciones suaves. Estamos buscando socios para el desarrollo conjunto y / o licenciatario.
  
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  The offered catalyst has the advantage of being easily prepared and of being one of the most active and stable reported to date. Hydrogenation of aromatics can be operated under mild conditions and under solvent free conditions, thereby rendering the process more sustainable and easy to implement. The catalyst can also be recycled at least 10 times without significant loss of activity, which makes it attractive for continuous flow applications. Leer más
O-1160University of Louisiana at Lafayette / Estados Unidos 998

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Método para la preparación de temperatura ambiente de Titania nanoesferas magnéticas recubiertas y otros Nanoestructuras

Titania, Titanium dioxide, nanoparticles, magnetic, ferrite, micelle, photocatalytic; germicidal
- Descripción de la oferta tecnológica :
  
  El dióxido de titanio (óxido de titanio) es uno de los productos químicos más demandados del mundo debido a su alta versatilidad de uso. Investigadores de la Universidad de Louisiana en Lafayette han desarrollado un método para la preparación de compuestos, nanoesferas compuestas de un núcleo de ferrita de níquel y que tiene una cáscara de dióxido de titanio (óxido de titanio) con actividad fotocatalítica y germicida. Esta tecnología utiliza una metodología química micela inversa patentada que no requiere maquinaria cara o temperaturas elevadas. (Ref. US7504130, US7964013, US8197890, US7635518).
  
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  Permits 100% titania availability and minimizes nonavailable, internal titania waste (in contrast to mixed
  titania / ferrite composites);
  • Modified reverse micelle chemistry is performed at room temperature and without the need for
  expensive machinery;
  • Permits removal of titania nanoparticles from liquid solutions and environmental sources (a current EPA concern) via magnetic manipulation;
  • Demonstrated germicidal and photocatalytic coating for industrialand biomedical uses;
  • Reusable means of decontamination, chemical reduction (N2 & CO2) and catalysis;
  • Other preferred applications of this technology include custom shaped magnetic nanorods
  (US8197890, US7635518) and nanospheres for ultrahighdensity storage media (US7964013). Leer más
O-915CIBER-BBN / España 932

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Nuevo sistema de administración para la terapia del cáncer colorrectal

Colorectal cancer, cancer, therapeutic, Drug delivery, peptide, DNA, siRNA, tumor
- Descripción de la oferta tecnológica :
  
  Hemos desarrollado un nuevo sistema de administración de fármacos para el tratamiento selectivo de las células tumorales colorrectales. Hasta ahora, las pruebas de administración in vivo han tenido éxito, mostrando la internalización mediada por receptor celular específico del transportador en tejidos tumorales y en metástasis a dosis bajas. Además, los transportadores han mostrado una alta estabilidad en el animal, sin toxicidad aparente.
  
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  We have developed modular single chain polypeptides obtained by recombinant DNA procedures, capable of self-assembling as nanoparticles, and able to recognize specific cell-surface markers and deliver therapeutic proteins, DNA or RNA to specific cell types involved in the development and progression of colorectal cancer.
  
  As shown by tagged ones, our peptide nanoparticles are able to internalize desired therapeutic molecules into the cytoplasm or even the nucleus of cultured tumor cells. We are currently assessing the ability of the system to kill tumor cells by expressing therapeutic molecules in vivo.
  These nanoparticles, improve the performance of metal nanoparticles, since they are highly customizable, can bind a wide range of therapeutic molecules such as nucleic acids (shRNA, siRNA) or therapeutic proteins and show no toxicity in animals. This permits for an individualized and selective therapy scenario.
  
  The surface receptor to which our tag binds to is overexpressed in aggressive tumors and metastasis. So far, we have focused on the treatment of CRC. In the near future, we are planning to target other tumor types, such as glioblastoma or hematological neoplasias. Leer más
O-1155University of Louisiana at Lafayette / Estados Unidos 740

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Nanoestructuras de ultra alta densidad de almacenamiento de medios

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles
- Descripción de la oferta tecnológica :
  
  En el calor de grabación magnética asistida (HAMR), partículas compuestas FeRh-FePt se utilizan ampliamente para aumentar la estabilidad térmica y superar las limitaciones de campo de escritura en grabaciones tanto longitudinales y perpendiculares magnética. Las nanopartículas esféricas ofrecen medios magnéticamente isotrópicos con ventajas funcionales respecto las partículas convencionales. Por lo tanto, la síntesis de nanopartículas esféricas compuestas de FeRh-FePt ofrecen un gran potencial para aumentar la estabilidad de los medios de almacenamiento magnético y función. Esta oferta tecnológica incluye métodos y procesos para la fabricación de Ferh / FePt nanoestructuras núcleo-envuelta y su uso como un medio de almacenamiento de ultra-alta densidad.
  
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  In HAMR, both the coercivity and saturation magnetization of FePt are lowered during the heating process.However, the lowering of saturation magnetization of FePt reduces the thermal stability of the FePt media and therefore the ability of the FePt media to maintain written data over time. By magnetically coupling FePt with FeRh, the saturation magnetization of the FeRh--FePt system is increased over that of FePt alone, resulting in an increase in the thermal stability of the magnetic recording media and solving the write-ability problem.Therefore the synthesis of FeRh and the magnetic coupling of with FePt overcomes the write field limitations in both longitudinal and perpendicular magnetic recordings. This current technology offering includes methods and processes for making uniformly spherical FeRh/FePt core shell nanostructures and their demonstrated use as an ultra-high density storage media. This technology has significant potential as a ultra-high density storage media. Leer más
O-893GAIKER, Technological Centre / España 167

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Active packaging, encapsulation of active components. Microencapsulation through different technologies, supercritical fluids and spray-drying. Improve of the barrier properties.

active packagingcoatings, antimicrobial, Microencapsulation, supercritical fluids, spry-drying, odour
- Descripción de la oferta tecnológica :
  
  Microencapsulation of active components:
  - Natural antioxidal (polyphenols,axtansatinas)
  - Oxygen absorbers
  - Flavor
  - Antimicrobial (organic and inorganic)
  
  Addition of these components in the materials: extrusion or compounding (PA, PE, EVA, PCL and PLA)
  
  Use of theses materials for active packaging to increase the shelf life of foods, to improve the packaging and protect from microbial organism spoilage
  Improve of the barrier properties.
  
  Using two different technologies supercritical fluids and spry- drying.
  
  Functionalization of nanoparticles with active properties.
  
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  Aspectos nuevos e innovadores
  
  Development of materials with new functions and improved properties for packaging.
  - Improve the barrier properties.
  - Increase the self life of foods
  - Improve the packaging quality
  - Protect the food against microbial organism
  - Odor removal
  - Controller released of odor
  - Controller released of different actives (vitamin C…)
  
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O-895GAIKER, Technological Centre / España 155

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Development of smart materials, design, formulation, transformation and characterization of magneto-rheological fluids, conductive polymers, memory shape polymers, piezoelectric materials and nano particles

smart material, smart textil, conductive polymer, shape change material, phase change material, Nanotech
- Descripción de la oferta tecnológica :
  
  Smart materials development, formulation, processing and testing of:
  
  - Magneto-rheological fluids: change their rheological characteristics under the influenceof a magnetic field. This change is reversible and instantaneous.
  - Compounds with different level of electrical properties: Piezo electric polymers, intrinsic and extrinsic conductive polymers.
  - Active material compound: thermoplastic and thermoset materials with active properties, antibacterial, photoactive, chromoactive…
  - Smart textiles: Development of filament with new properties like conductivity, memory shape, color change…
  - Smart structures development.
  - Integration of phase change materials.
  - Nanoparticles: synthesis processing, and characterization of nanomaterials, organic, inorganic and hybrid with different properties.
  
  Transformation of materials through different technologies and process:
  
  - Micro-encapsulation technology, supercritical fluid technology for extraction or impregnation, Injection,Compression,Infusion,RTM, SMC,
  
  Characterization of the materials, mechanical properties, IR, UV, rheological properties thermal properties, microscope TEM,SEM
  
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  Development of thermoset and thermoplastic materials with new functions and improved properties
  
  - Nanotechnology in order to improve materials properties like fire resistance, impact resistance, mechanical properties…
  - Combination of properties: light weight materials with high mechanical properties and fire resistant coating
  - Materials with low environmental impact and use of recycled materials
  - Smart textiles
  - Active materials
  - Smart structures
  - Conductive polymers
  - Microencapsulation
  - Supercritical fluids
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O-591AMIC innovation centre and CATHETER research group / España 800

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Characterization and quality tests of materials, catalysts, solutions

Characterization, activity tests, materials, nanoparticles
- Descripción de la oferta tecnológica :
  
  Diseño, SÍNTESIS, modificación y caracterización de materiales, nanomateriales, soluciones, catalizadores. Evaluación de la eficiencia, selectividad y del ciclo de vida de estos materiales. El equipo de PhD de AMIC es experto en la síntesis y modificación de diversos materiales como hidrotalcitas, zeolitas, carbón activo, óxido de aluminio, nanopartículas con Ag, Au, Pt, Cu, Pd, Ni. El objetivo de este conocimiento es obtener diferentes aplicaciones en nuevos procesos
  
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  AMIC owns all kind of equipments to study the properties of the materials;
  X- Ray diffraction, TEM, SEM, physisorption, IR, TPR/D/O, hydrogen chemisorption, microwaves, etc
  AMIC owns also lab pilot plants, in order to simulate and study the reaction required by the client.
  
  In addition to the characterization AMIC offers you the know-how in different materials, with some modification proposals in order to improve your materials. Leer más
O-475University of Alicante / España 939

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Procedimiento novedoso para sintetizar sólidos mesoporosos de forma controlada.

mesoporous solids, carbon materials, environment, polioxometalates, POM, Catalyst, nanoparticles
- Descripción de la oferta tecnológica :
  
  El grupo de investigación “Materiales carbonosos y medio ambiente” de la Universidad de Alicante ha desarrollado un novedoso procedimiento que permite sintetizar sólidos mesoporosos a partir de cualquier sal basada en polioxometalatos (POM) de forma controlada, tanto en volumen como en tamaño. Es un método muy sencillo y eficiente que genera un gran volumen de mesoporosidad homogénea en el seno de las nanopartículas, dando como resultado compuestos que se utilizan como catalizadores y/o soportes de catalizadores más económicos y medioambientalmente menos perjudiciales que los empleados actualmente por la industria química. El grupo de investigación busca empresas interesadas en adquirir esta tecnología para su explotación comercial.
  
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  This method is unique in the market and implies a simple procedure to control the volume and size of the mesoporosity developed in POM-based salts. This is possible thanks to the pH increase in solution during the synthesis of mesoporous solids.
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O-444CIBER-BBN / España 1600

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Oferta tecnológica >> micro-cámara para el monitoreo de cultivos celulares mediante resonancia magnética nuclear

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors
- Descripción de la oferta tecnológica :
  
  La presente invención comprende un dispositivo de micro-cámara para el cultivo celular que permite el seguimiento a largo plazo de sistemas celulares mediante RMN y otras técnicas de imagen. Pueden realizarse análisis de imagen y estudios metabólicos. Permite evaluar el efecto de agentes activos, tales como medicamentos, nanopartículas o factores biológicos. Con su utilización se adquiere un mejor conocimiento de las condiciones fisiológicas y patológicas, lo que ayudará en los diagnósticos y tratamientos.
  
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  Está hecho de materiales biocompatibles en los que se pueden realizar estudios longitudinales a largo plazo de cultivos celulares. Es de un diseño y tamaño adecuado para los equipos de RMN disponibles en el mercado. Es un material transparente, por lo tanto, también es útil para otras técnicas microscópicas. Cuenta con un sistema de difusión para la distribución uniforme de las células. Pueden controlarse las propiedades fisicoquímicas del cultivo mediante sensores de fibra óptica para pH, pO2, pCO2, PNO, o pSH2. Tiene una alta ... Leer más
O-896GAIKER, Technological Centre / España 140

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Development of thermoplastics and thermoset materials, formulation, aditivation, nanoaditivation, compounding, transforming processes, characterization and testing (mechanical properties, chemical, fire resistant, impact resistant….)

Antifouling, natural fibers, coating, biocomposites, resins, antiscratch, lightweight materials, insulation
- Descripción de la oferta tecnológica :
  
  From the initial formulation of the raw material to finished product.
  
  Development of new formulation: to get new properties and functionalities
  - Nanoparticles
  - Natural fibers
  - Paints and Coatings
  - Lightweight materials
  
  Transforming processes for both thermoplastic and thermoset materials
  
  - Injection molding
  - Compression
  - SMC/BMC
  - Pultrusion
  - Filament wilding
  - RTM
  
  Characterization and testing according to the required standard
  - Mechanical laboratory
  - Coatings laboratory equipped with application facilities
  - Microscopy laboratory (EDAX,SEM,TEM…)
  - Rheology laboratory
  - Fire resistance laboratory
  
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  Aspectos nuevos e innovadores
  
  - Reduced weight but not mechanical properties
  - Improved mechanical properties
  - Bio-composites, thermoplastics or thermosets with natural fibers.
  - Improved anti-scratch properties
  - Antimicrobial materials
  - Conductive plastic
  - FMR (Fluids Magnetorheologic)
  - Shape memory polymers
  - Adding recycled materials
  - Improved thermal insulation properties
  - Improved acoustic insulation properties
  - Antifouling
  - Self-cleaning surfaces
  - Reduce curing cycle time, alternative systems (microwave…)
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O-70EryDel Spa / Italia 1800

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Method of encapsulating biologically active agents within erythrocytes, and apparatus thereof.

Blood, pharmaceutical, Drug, Delivery, Therapy, Diagnostic, Encapsulation.
- Descripción de la oferta tecnológica :
  
  Innovative therapies and diagnostic tools based on the use of autologous red blood cells as agent carriers, selective drug target system, agent passive reservoirs and circulating bioreactors.
  The company own a proprietary technology that allow to encapsulate any kind of active agents within a small quantity of autologous blood with automatic, reliable and a reproducible system.
  
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  The method’s principle is based on the possibility of temporarily opening the Red Cells’ membrane pores measuring 200-500 Å, through which the products to be encapsulated (conventional drugs, peptides, proteins, nucleic acids, dyes, nanoparticles, etc.) can be carried. These pores are then sealed again and the drug excess which is not encapsulated, is washed out. Once administered back to the donor, these erythrocytes circulate normally, maintain their property of oxygen transporters, maintain a normal morphology and normal biochemical and reological features.
  
  This procedure is currently achieved thanks to an equipment called “Red Cell Loader” and a dedicated CE Marked disposable kit. The system is completely automatic, easy to use and to handle, reliable and highly reproducible.
  
  The kit and the equipment can be used directly by medical personnel in the hospital or in the clinic without any specific environmental requirement. Leer más
O-918CIBER-BBN / España 1019

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Nuevo sistema de administración de sustancias a células senescentes

senescent cells, senescence studies, nanodevices, Drug delivery, Biomarkers, cosmetics, β-Gal, Beta-Galactosidase, diskeratosis, fibroblasts, senescent-associated diseases, nanoparticles
- Descripción de la oferta tecnológica :
  
  Esta innovación se refiere a nanodispositivos para la administración controlada y específica de sustancias (fármacos, bio-activos, marcadores, cosméticos) a las células senescentes. El nanodispositivo comprende un transportador que transporta la sustancia y permite su liberación, cuando alcanza las células diana, por medio de la interacción con la beta-galactosidasa (SA-b-Gal) asociada a la sensecencia. Por lo tanto, es útil para los estudios de senescencia, la prevención y el tratamiento de enfermedades asociadas a la senectud. Además de otras enfermedades en las que la β-Gal esta específicamente presente o aumentada. La innovación también comprende los procedimientos de preparación y uso de los nanodispositivos. La innovación pertenece a los campos farmacéutico y cosmético.
  
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  A first aspect of the invention refers to a nanodevice (25 to 150 nm diameter) for the controlled delivery of substances. The liberation of the cargo in the cells is activated by the presence of a senescence-associated enzyme.
  
  Other aspects of the invention are: preparation procedures of nanodevices; pharmaceutical compositions and medicaments comprising nanodevices; their use to treat or prevent diseases where b-galactosidase is over-expressed; the uses of these nanodevices for the detection and quantification of senescent cells, and for the manufacture of cosmetic compositions.
  The cargo can be a marker, a compound for re-activation of telomerase, a cytotoxic compound, or any mixture of them. These substances selectively delivered can prevent, eliminate/replace, detect or mark senescent cells.
  
  Inventors have shown the liberation of cargo in the presence of b-Gal: (a) in a aqueous solution; (b) intracellular delivery of cargo in cultures of a strain of S. cerevisiae expressing b-Gal, opposite to wild type used as control; (c) selective delivery of substances to senescent cells in human cell cultures, dermis fibroblasts from two patients with congenital diskeratosis related to sex (X-CD) versus control fibroblasts, H460 lung cancer cells expressing telomerase (no senescent cells), and primary human cells. Viability studies showed that nanodevices of the invention are not toxic for human cells.
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O-837UATEC - Technology Transfer Office of University of Aveiro / Portugal 1631

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Reactor óhmico para la síntesis química, el método y sus aplicaciones

reactor, heating, ohmic, chemical synthesis
- Descripción de la oferta tecnológica :
  
  Un grupo de investigadores de tres universidades públicas ha desarrollado un reactor de calentamiento óhmico para la síntesis química, en particular en medios acuosos. Este reactor y el método de calentamiento ha encontrado aplicación en la síntesis orgánica e inorgánica, preparación de materiales organometálicos, síntesis de nanopartículas y polímeros, siendo aplicable en la industria química y farmacéutica. Su simplicidad y el bajo coste del reactor, su baja capacidad térmica y la inercia térmica, el calentamiento rápido y uniforme, su alta eficiencia, facilidad de mantenimiento y manipulación, así como la posibilidad de un control visual de la evolución de reacción y la posibilidad de la adición de reactivos durante el curso de la reacción, hacen de este reactor una opción versátil y ventajosa para los procedimientos de síntesis química
  
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  In ohmic heating electrical energy is dissipated in heat with a very high efficiency (electrodes in contact with the reaction medium), resulting in fast and uniform heating and in the increase of charged species movement. As in the case of the heating with microwave radiation, electrical energy is transformed into thermal energy. However, on contrary of heating with microwave radiation (penetration depth of microwave radiation in absorbing media is limited) the penetration depth is virtually unlimited and the extent of heating is regulated only by the spatial uniformity of electrical conductivity throughout the reaction medium and the time spent in the ohmic reactor. Thus, the direct scaling of the ohmic heating for the pilot or industrial scale shouldn’t have the limitations presented by microwave radiation heating. It is also possible to reduce reaction times and increase the energy efficiency of chemical reactions Leer más
O-988Gaiker, Technological Centre / España 1768

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Nuevo e innovador revestimiento anti-arañazos puede ser utilizado en sectores diferentes, como automóviles, muebles ...

antiscratch, Automotive, Construction, Antifouling, clear coating formulatio, nanoparticles, antibacterial
- Descripción de la oferta tecnológica :
  
  Nuevo e innovador revestimiento resistente a los arañazos con excelente:
  - Retención de brillo después de la abrasión
  - Aspecto estético
  - Principalmente brillo
  - transparencia
  - Funcionalidades adicionales podrían sumarse de acuerdo a sus especificaciones o requisitos
  
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  These systems have enhanced scratch resistant properties compared to the commercial systems.
  
  Also coatings with self healing properties, enhanced fire reaction or intumescent properties can be formulated.
  
  The application technology for all these systems is the conventional one for coatings, it is no needed investment in new machines or special robot for the application.
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O-894GAIKER, Technological Centre / España 127

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Development of fire resistant thermoset and thermoplastic materials. Reaction to fire test laboratory, accreditted certificate ENAC nº 72/LE187.

Fire resistant material, thermoset material, thermoplastics material, resins, Coatings, intumesce, nano
- Descripción de la oferta tecnológica :
  
  Fire resistant thermoset and thermoplastic materials development and formulation.
  
  Transformation of materials through different technologies and process, RTM, SMC, Compression Injection
  
  Characterization of the materials, mechanical properties, thermal properties, UV absorption properties…
  
  Reaction to fire test, regulation:
  - Construction sector: EN 13501-1
  - Transport sector: CEN TS 45545-UNe 23727-90-NF F16101-Directive 95/28/CE
  - Electric and electronic sector: EN ISO 4589-EN ISO 60695-2 – EN 50267
  
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  Aspectos nuevos e innovadores
  
  New development of thermoset and thermoplastic materials.
  
  - Nanotechnology in order to improve materials properties like fire behavior, impact resistance, mechanical properties…
  - Combination of properties like: light weight materials with high mechanical properties and fire resistant coating
  - Materials with low environmental impact and use of recycled materials
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O-412CIBER-BBN / España 1569

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Optimized histological method for the preservation of epitopes and cellular architecture.

histological methods, vertebrate tissues,
- Descripción de la oferta tecnológica :
  
  Its a new method for the optimal preservation of the morphology and the maintainance of the reactive properties of vertebrate tissue in histological samples. It represents a good alternative to classi histological methods usually used for studying vertebrate embryogenesis in order to solve such common problems as lability of epitopes or as processin samples where rigid tissues intercalates between soft ones.
  
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  This invention develops an optimized new method for the histological and histochemical preservation of tissue. It is compatible with any staining method. The optimization with respect to the present techniques is achieved by the combination of fixing and inclusion conditions and the use o the appropiate chemicals and materials for fixation and inclusion, allowing a very high preservation of the morphology and reactive properties of the tissue. Leer más
O-411CIBER-BBN / España 1560

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Novel pharmaceutical composition comprising mesenchymal stem cells placed in a compound membrane for the treatment of osteochondral lesions

osteochondral lesions, osteochondritis, traumatology, bones, cellular biology, Biomedicine, Biomater
- Descripción de la oferta tecnológica :
  
  The present invention refers to a pharmaceutical composition comprising mesenchymal stem cells placed in a compound membrane, its obtaining method, and its use for the treatment of osteochondral lesions. The present invention belongs to the biomedical, biotechnologycal, cellular biology and regenerative fields.
  
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  Thanks to this product, in the chondro-osteo-articular lesion a regenerative tissue is formed equal to the adjacent cartilage in the three cartilaginous strata, and equal to the subchondral bone in the organization of the cells, and in the amount and quality of either the cartilaginous or the bone surrounding matrix.Tje generated tissue integrates in a permanent way in the receptor tissue, and, besides, it is functional regarding its response to loads. Leer más
O-410CIBER-BBN / España 2200

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Thermomagnetic aplicator device for the treatment of altered processes of the electrical conductivity, in the central nervous system, with local inflammation

Biomedicine, Bioengineering, Nanomedicine, magnetic fields, inflammatory processes.
- Descripción de la oferta tecnológica :
  
  This invention belongs to the biomedical engineering field, and develops a thermomagnetic applicator device. This device is configured to generate (i) heat and (ii) a magnetic field of extremely low frequency, in order to be applied in processes of altered electrical conduction in the central nervous system with inflammatory response.
  
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  Aspectos nuevos e innovadores
  
  At present, we do not know any thermomagnetic stimulator to be applied in inflammatory processes of altered conductivity in the central nervous system.
  The device has a surface in order to apply the magnetic field and heat and it is equiped, as well, with a unit to generate the magnetic field and heat.
  
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O-407CIBER-BBN / España 1733

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New derivatives of small interfering RNA (siRNAs), and their processes of synthesis

Biomedicine, Nanomedicine, siRNA, Crohn's disease, inflammation, colitis, cancer, gene expression
- Descripción de la oferta tecnológica :
  
  This invention describes new derivatives of small interfering RNA (siRNAs), and their processes of synthesis. The modified siRNA, according to this invention, improves its entry to cells and its stability to nuclease degradation, increasing the inhibitory capacity of the siRNAs. Pharmaceuticals compositions are also described as well as their medical uses.
  
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  Aspectos nuevos e innovadores
  
  Improved stability of the resulting siRNA duplex.
  
  Improved entry of those siRNA into cells.
  
  Higher stability in front of degradation by nucleases and therefore they are able to keep the gene silencing for longer periods than unmodified siRNA.
  
  The administration of these compounds can be oral, parenteral, intravenous, intramuscular, subcutaneous and intra-duodenal. Leer más
O-405CIBER-BBN / España 1680

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Partículas magnetico-luminiscentes para aplicaciones biomédicas (marcadores de células y agentes terapéuticos, agentes de contraste de RMN y trazadores ópticos, terapia génica)

biomedical aplications, biomolecules, Biomedicine, cell markers, therapeutic agents, NMR, biosensors, hyperthermia, Drug delivery, Gene therapy, Bioengineering, Nanomedicine
- Descripción de la oferta tecnológica :
  
  La presente innovación comprende un sistema de partículas con propiedades tanto magnéticas como luminiscentes, y el procedimiento para ser obtenidas. El tamaño de estas partículas es menor que tres micras, particularmente menos de 500 nm. Las partículas pueden ser funcionalizadas con moléculas o grupos químicos, haciéndolos especialmente útiles para Aplicaciones biomédicas. Debido a sus propiedades magnéticas, responden al campo magnético (orientación, la hipertermia, la imagen de RMN) y debido a su luminiscencia puede ser utilizado como una señalización óptica y sistema de detección.
  
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  Aspectos nuevos e innovadores
  
  The particle surface can be modified by linking molecules or functional groups, forming a biocompatible coating. In vitro assays have shown that both types of particle,functionalized or not, are not cytotoxic. These studies also show that these particles can be efficiently internalized into cells through interaction with specific membrane receptors. The viability rate of the cells, in the presence of these particles, was 95-98%, after 72 hours in culture. Leer más
O-1063UATEC - Technology Transfer Office of University of Aveiro / Portugal 581

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Termómetro molecular luminiscente

Molecular thermometer, temperature sensors, sensors, temperature
- Descripción de la oferta tecnológica :
  
  Científicos de la Universidad de Aveiro y una institución española han desarrollado un termómetro molecular luminiscente que es capaz de enviar información con alta resolución espacial acerca de la temperatura absoluta en la forma de señales de luz que se pueden detectar con alta sensibilidad y persistencia. El termómetro molecular luminiscente puede ser procesado en medios poliméricos o integrado en un híbrido orgánico-inorgánico matriz a base de siloxano. Se busca socio industrial interesado en la licencia de esta tecnología.
  
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  Aspectos nuevos e innovadores
  
  In its current state of development, the molecular thermometer qualitatively exceeds current performances in accuracy, space resolution, reliability and ease of use. The molecule, however, and the host matrix, accept modifications that can further extend thermometric properties and commercial uses, e.g., maximum temperature sensitivity can be tuned to specific temperature ranges and wavelength emission can be moved towards ad hoc ranges for specific applications, like near infrared range where biological tissues have minimum absorption. These developments are currently under investigation by the Team. The molecular thermometer can also be processed in different matrixes, e.g., in a ureasil matrix as paint, to enable new applications and possibilities: microelectronics, catalysis, etc. As a molecular system it allows fine tuning to optimise its response at each specific application Leer más
O-619CIBER-BBN / España 2171

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Dispositivo médico ocular para "retinal re-attachment" y su tratamiento post-operatorio

ophthalmology, retina, retina detachment, retina reattachment, surgery, technology, health, medicine
- Descripción de la oferta tecnológica :
  
  La presente invención describe un dispositivo útil para la re-unión de la retina y su tratamiento posterior a la cirugía. Dirigido a la micro y nanotecnologías para la salud y aplicaciones biomédicas, en particular a la optimización de la cirugía oftalmológica
  
  El dispositivo, proporcionado por esta invención mantiene el agujero retiniano cerrado y mejora el bienestar del paciente después de la cirugía. Sus componentes son inyectados a nivel intra-ocular y se colocan en la zona que cierra los orificios de la retina que han causado el desprendimiento.
  
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  Aspectos nuevos e innovadores
  
  The device was tested in rabbits. Results showed a 90% success in the retina re-attachment after one week. Furthermore, no side effects have been detected.The high incidence of retinal detachment places this pathology as a priority for ophthalmologists, particularly the technological challenge of achieving an efficient system to close the break due to retinal hole.
  
  - Multiple retinal holes can be closed
  - More than one device can be placed
  - It can be used in procedures with and without vitrectomy, in scleral buckle surgery, or pneumatic retinopexy
  - Proper healing of retinal holes
  - Increase the success rate of retinal re-attachment
  - Lack of side effects, including cataract, inflammation as well as recurrence
  - Upright position is allowed to patients
  - Good post-surgery visual acuity
  - Free visual axis.
  - No refractive effects, immediately after surgery
  - No components dispersion within the eye, located on the retina inner limiting membrane
  - No optical effect, differing from gases and silicones filling the eye in other treatments
  - Excellent conditions of pressure on the retinal surface. Pressure ranges from 0.05 to 2 mmHg
  - Contact surface increases
  - Biocompatible Leer más
O-921CIBER-BBN / España 1154

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Nuevo dispositivo de cultivo celular

Substrate, screening, Cell, Culture
- Descripción de la oferta tecnológica :
  
  La presente innovación se refiere a un dispositivo encapsulado (lab-on-chip) útil para estudiar los cultivos celulares. Se hace preferiblemente de un material plástico que tiene varios pocillos de cultivo. Los fondos de los pocillos se cubren con un material gelificado, que difieren de las propiedades mecánicas en cada pocillo. El objetivo de la innovación es la producción de sistemas de alto rendimiento de análisis capaces de estudiar la respuesta celular en función de la rigidez del sustrato gelificado.
  
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  It is known that the mechanical properties of the substrates have an important effect in the behavior and development of cell cultures. Among them, rigidity is especially relevant. Therefore, research groups in this field increasingly need available samples on substrates with different rigidity. To date, such experimental devices have been individually developed by researchers for their own necessities, for single use and lacking of general application. Therefore, there is a necessity of developing high throughput analytical systems to, easily and quickly, characterize cell culture response to different rigidity of substrates. The present invention is aimed at fulfilling this necessity.
  
  A lab-on-chip device has been developed to be use in high throughput analysis of cell cultures, allowing the study of their growth and response to the environment (culture condition, culture medium, drugs, etc.) depending on the substrate rigidity. This device comprises a gel maker with, at least, two entry channels, a mixer to create a mixing gradient, exit channels connected to a multi-well culture chamber, allowing gels differing from rigidity to be deposited, as substrate, in different wells. The culture chamber also comprises entry and exit channels for culture medium, cells, and agents (biological factors, drugs, etc.) to be added to the wells. This invention comprises the device itself, the culture method using this device, and the manufacturing process of the device. Leer más
O-919CIBER-BBN / España 864

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Nuevos liposomas funcionalizados para el suministro de compuestos bioactivos

liposomes, liposome, Drug delivery, bioactive compounds, therapeutic agents, medicaments, medicament, pharmaceutical composition, Fabry disease, cosmetics
- Descripción de la oferta tecnológica :
  
  La presente innovación está relacionada con un nuevo tipo de liposoma funcionalizado, para el suministro selectivo de agentes activos. Este liposoma lleva un conjugado, por medio de la funcionalización del esterol presente en su bicapa lipídica con un polímero, unidos por un enlace no-carbamato (diferente al estado de la técnica).
  
  Además, el polímero esta funcionalizado también con un ligando que hace de guía. Este conjugado mejora las propiedades físico-químicas de las vesículas que llevan, haciendo que esten más estables y homogéneas. Se puede describir el procedimiento para su preparación, la composición farmacéutica que contiene estos liposomas, y su uso terapéutico.
  
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  A first aspect of the present invention is a conjugate comprising: i) a sterol; ii) a polymer bond to the sterol by means of a no-carbamate bond; iii) a guiding ligand, capable of selectively binding to receptors present in a target cell. This ligand is covalently bond to the polymer. A preferred embodiment is that where the sterol is cholesterol.
  
  Other aspects of this invention are: a liposome comprising a conjugate as previously defined; liposome comprising a therapeutic agent; the use of the liposome as a delivery system for therapeutic agents; the use of the liposome as medicament; a pharmaceutical composition comprising an affective amount of liposome together with excipient or acceptable pharmaceutical carriers; and procedures to prepare the conjugate and the liposome. In a preferred embodiment, the invention comprises the use of the liposome to prepare a medicament for the treatment of Fabry disease, as well as its administration method. Leer más
O-917CIBER-BBN / España 1679

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Nuevo Péptido biomimético osteogénico

peptide, Osteogenic, bone, Regeneration, Disease, lesion, tissue, Implant, prothesis
- Descripción de la oferta tecnológica :
  
  La presente innovación comprende un péptido con capacidad osteogénica, la secuencia de nucleótidos que codifican para este péptido, así como una construcción genética que contiene dicha secuencia, un vector que contiene esta secuencia, y una célula huésped que contiene este vector. La innovación también comprende el uso del péptido, o su composición farmacéutica, para la regeneración ósea o recubrimiento de implantes y prótesis.
  
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  The peptide consists of a region capable of binding to collagen type I, and a domain allowing the anchorage of osteoblasts, therefore stimulating bone formation where it is located. The peptide of the invention can act by itself or linked to a collagen matrix. Therefore, aspects of the invention refer to the following compositions: matrix of type I collagen comprising the peptide of the invention, matrix of type I collagen comprising the peptide and a bone morphogenetic protein (BMP).
  
  Besides, the invention refers to the use of the peptide and these matrices as medicaments or for the elaboration of medicaments for the treatment or prevention of bone diseases or lesions. This peptide stimulates a cellular increase of osteoblast differentiation marker, alkaline phosphatase. When ectopically implanted in rats, a great production of bone tissue was observed.
  
  The peptide or the mentioned matrices can be used for the coating of implants or prostheses. Due to these coatings, prostheses and implants present the capacity of regenerating bone, and allow the localized application of the peptide or the matrix, minimizing dispersion and favoring a better effect when used. Leer más
O-916CIBER-BBN / España 749

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Nuevos copolímeros anfifílicos con propiedades antitumorales

cancer, antitumoral, Drug delivery, hydrophobic, Hydrophilic
- Descripción de la oferta tecnológica :
  
  La presente innovación describe el uso de una familia de copolímeros anfifílicos que forman micro-o nano-micelas, con intrínseca actividad anti-tumoral, y también como transportadores para otros agentes anti-tumorales. Los compuestos de la presente innovación están constituidos por monómeros acrílicos y monómeros altamente hidrófilos.
  
  Presentan actividad intrínseca antitumoral y antiangiogénica. También pueden usarse como transportadores para otros principios activos anti-tumorales. Estos anfifílicos co-polímeros tienen la capacidad de formar micelas de tamaño nanométrico y micrométrico, con núcleo hidrófobo y envoltura hidrófila.
  
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  A first aspect of the invention refers to the synthesis procedure for obtaining these polymeric compounds. A second aspect of this invention refers to the use of the polymeric compounds for the manufacture of a pharmaceutical composition for the treatment of cancer. A third aspect of the invention refers to the procedure to obtain the micelle particles. Furthermore, it refers to the micelle particles as pharmaceutical vehicles, since they can encapsulate anti-tumoral agents, and can be used for the manufacture of pharmaceutical compositions.
  
  Finally, viability tests, demonstrated the low toxicity of the co-polymers. These compounds significantly decrease the cellular viability of carcinogenic cells without affecting the healthy ones. Besides, they present anti-angiogenic activity. It was observed that co-polymer particles entered the cells, and were accumulated around the nucleus within six hours of incubation. Leer más
O-1027CIBER-BBN / España 684

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Anticuerpos para la detección y cuantificación de los anticoagulantes

Antibodies, antibody, anticoagulants, diagnostic tools, diagnostics, POC, point of care, point of care devices, Hapten, immunoassay, ELISA
- Descripción de la oferta tecnológica :
  
  El aspecto clave de esta innovación es el diseño de las estructuras de los haptenos inmunizantes y su síntesis, capaz, en consecuencia, de la generación de anticuerpos específicos. Permite un seguimiento mucho mas completo de la respuesta del paciente a la medicación.
  
  Dispositivo PoC permite llevar a cabo pruebas de diagnóstico fuera de un laboratorio clínico y por personal no especializado, de forma automatizada, en miniatura, y no invasivos, con diagnósticos rápidos y de pequeño volumen de muestra, fácil de obtener.
  
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  Treatment with coumarin-like anticoagulants requires periodic monitoring, and follow-up of its effect in the patient.
  
  A key aspect of this invention is the design and synthesis of haptens structurally related to coumarin-like anticoagulants (CAC) capable, as a result, of generating specific antibodies against this kind of compounds. With these antibodies, inventors developed a diagnostic tool allowing the quantification of CAC plasma level in treated patients. The immunochemistry procedure for analysis and assessment of patient samples can be use in any type of immunoassay format, such as ELISA, western-blot, immunoturbidimetry, immunosensor, etc.
  
  Aspects of the invention are the haptens; their preparation procedure; conjugates comprising a hapten and a carrier, with immunogenic activity inducing the formation of antibodies; antibodies recognizing specifically conjugates of the invention and coumarin-like anticoagulants; antisera comprising these antibodies.
  
  Additionally, the invention is related to the use of the antibodies or the antisera for the detection or quantification of coumarin-like anticoagulants in samples from subjects, the method, and the kit for such detection.
  
  Furthermore, the invention considers an analysis tool for immediate diagnostics, known as PoC (point-of care), as a portable coagulometer, and its use for the quantification of anticoagulants in a subject sample. Leer más
O-1146CIBER-BBN / España 358

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Preparación de nuevos miméticos RGD "Ready-for-click"

Osteogenic, biomaterial, surface, click reaction, OGP, RGD, mimetic, nonpeptide
- Descripción de la oferta tecnológica :
  
  La presente invención se refiere al desarrollo de la nueva RGD o OGP10-14 de materiales miméticos no peptídicos capaces de unirse a la superficie de biomateriales por una sola operación química "click". Los peptidomiméticos unidos de esta manera son estables y no sufren reacciones de degradación en condiciones fisiológicas. Estos miméticos no peptídicos son particularmente útiles para dispositivos médicos, incluyendo los implantes endoóseos, o tejido de ingeniería andamio o matriz de cultivo de células, son adecuados para la sustitución o regeneración de órganos humanos y animales.
  
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  Aspectos nuevos e innovadores
  
  The new nonpeptide mimetics of RGD or OGP10-14 allow to conduct in a single chemical operation the “click” bonding on the surface of a material. The peptidomimetics bound in this way are stable and do not suffer degradation reactions under physiological conditions. Preparation of new implants and medical devices with improved osteogenic properties.
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5TH NEW PRODUCT DEVELOPMENT AND INNOVATION MANAGEMENT

3rd Annual Alliance Management for Open Innovation in Pharma

XXIV ISPIM Conference, 16-19 June 2013, Helsinki, Finland: Innovating in Global Markets:

The 6th ISPIM Innovation Symposium – Innovation in the Asian Century

Innovación en nanoparticles : Oportunidades ... | Ofertas

Innovación en nanoparticles : Oportunidades ... | Ofertas

metal, nanoparticles, fluorescent, Biomarkers, contaminants, Quantum Dots.

metal nanoparticles, nanoparticles, raman spectroscopy, spectroscopy, sensors, Organic compounds, organic contaminants, pesticides, agricultural, agriculture, phytosanitary, Water

ruthenium nanoparticles, catalysts, hydrogenation of aromatics, fragrances, flavors, benzene hydrogenation, hydrogenation of phthalates, aromatics

Titania, Titanium dioxide, nanoparticles, magnetic, ferrite, micelle, photocatalytic; germicidal

Colorectal cancer, cancer, therapeutic, Drug delivery, peptide, DNA, siRNA, tumor

FeRh, FePt, recording, recording media, magnetic recordings, Storage, storage media, magnetic storage, Nanostructure, hardware, Electronics, computer science, nanoparticles

active packagingcoatings, antimicrobial, Microencapsulation, supercritical fluids, spry-drying, odour

smart material, smart textil, conductive polymer, shape change material, phase change material, Nanotech

Characterization, activity tests, materials, nanoparticles

mesoporous solids, carbon materials, environment, polioxometalates, POM, Catalyst, nanoparticles

This method is unique in the market and implies a simple procedure to control the volume and size of the mesoporosity developed in POM-based salts. This is possible thanks to the pH increase in solution during the synthesis of mesoporous solids. Leer más

NMR, cell culture, diagnostics, imaging, cellular culture, magnetic resonance, NMR, image techniques, drugs, nanoparticles, biological factors

Antifouling, natural fibers, coating, biocomposites, resins, antiscratch, lightweight materials, insulation

Blood, pharmaceutical, Drug, Delivery, Therapy, Diagnostic, Encapsulation.

senescent cells, senescence studies, nanodevices, Drug delivery, Biomarkers, cosmetics, β-Gal, Beta-Galactosidase, diskeratosis, fibroblasts, senescent-associated diseases, nanoparticles

reactor, heating, ohmic, chemical synthesis

antiscratch, Automotive, Construction, Antifouling, clear coating formulatio, nanoparticles, antibacterial

Nuevo e innovador revestimiento resistente a los arañazos con excelente: - Retención de brillo después de la abrasión - Aspecto estético - Principalmente brillo - transparencia - Funcionalidades adicionales podrían sumarse de acuerdo a sus especificaciones o requisitos

Fire resistant material, thermoset material, thermoplastics material, resins, Coatings, intumesce, nano

histological methods, vertebrate tissues,

osteochondral lesions, osteochondritis, traumatology, bones, cellular biology, Biomedicine, Biomater

Biomedicine, Bioengineering, Nanomedicine, magnetic fields, inflammatory processes.

Biomedicine, Nanomedicine, siRNA, Crohn's disease, inflammation, colitis, cancer, gene expression

biomedical aplications, biomolecules, Biomedicine, cell markers, therapeutic agents, NMR, biosensors, hyperthermia, Drug delivery, Gene therapy, Bioengineering, Nanomedicine

Molecular thermometer, temperature sensors, sensors, temperature

ophthalmology, retina, retina detachment, retina reattachment, surgery, technology, health, medicine

Substrate, screening, Cell, Culture

liposomes, liposome, Drug delivery, bioactive compounds, therapeutic agents, medicaments, medicament, pharmaceutical composition, Fabry disease, cosmetics

peptide, Osteogenic, bone, Regeneration, Disease, lesion, tissue, Implant, prothesis

cancer, antitumoral, Drug delivery, hydrophobic, Hydrophilic

Antibodies, antibody, anticoagulants, diagnostic tools, diagnostics, POC, point of care, point of care devices, Hapten, immunoassay, ELISA

Osteogenic, biomaterial, surface, click reaction, OGP, RGD, mimetic, nonpeptide

Usuario nuevo (registro gratuito)

Usuario registrado

This method is unique in the market and implies a simple procedure to control the volume and size of the mesoporosity developed in POM-based salts. This is possible thanks to the pH increase in solution during the synthesis of mesoporous solids.
Leer más

Nuevo e innovador revestimiento resistente a los arañazos con excelente:
- Retención de brillo después de la abrasión
- Aspecto estético
- Principalmente brillo
- transparencia
- Funcionalidades adicionales podrían sumarse de acuerdo a sus especificaciones o requisitos