Innovación en Enzymes : Oportunidades ...

O-1026University of Burgos / España 1041

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Microencapsulación de enzimas para acelerar el proceso de maduración de queso

microencapsulation of enzymes, food enzymes, cheese maturation, cheese ripening, cheese production, cheese, encapsulated enzymes, Dairy, food technology, food technologists, food ingredients
- Descripción de la oferta tecnológica :
  
  Investigadores de la Universidad de Burgos han desarrollado una tecnología de microencapsulación de enzimas proteolíticas en liposomas que reduce el tiempo del proceso de maduración del queso y el mantenimiento de sus características organolépticas. La adición de enzimas encapsuladas elimina los problemas asociados con la adición directa, la reducción de la maduración de tiempo y por lo tanto dando una salida más rápida del producto al mercado.
  
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  Application of microencapsulation to control the function and action of the enzymes involved in cheese ripening and shorten processing times. The addition of encapsulated enzymes eliminates the problems associated with the direct addition (loss of enzyme in serum, bad distribution, reduced performance and quality alteration cheese) allowing a gradual and control action, reducing time maturation and therefore giving a quicker exit of the product to market. Leer más
O-64ZURKO RESEARCH / España 1667

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Recombinant Enzymes Production - applications in food products

Biotechnology, Industrial Biohydrolysis, Biocatalysts Processes, Biomedicine, Molecular Diagnostics, Recombinant Enzymes
- Descripción de la oferta tecnológica :
  
  Zurko Research offers a quality service in the cloning, expression and purification of proteins on demand. Applications in dairy, meat and fish industry as well as in the feed production
  
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  This work is performed using DNA provided by the client. We use prokaryotic expression systems (Escherichia coli and Bacillus subtilis) as well of a yeast expression system (Pichia pastoris). We apply high standards in implementing quality services both technically and procedurally, that ensures high purity of the proteins we produce.
  
  In Zurko Research we perform cloning, expression and purification of proteins in bacterial or yeast systems. We develop new enzymes with interesting activities for the industry and compare them with commercial enzymes.
  
  In Zurko Research we develop pilot tests of these new enzymatic activities not yet described for its use in the industry. We also search for new enzymes with industrial interest focusing in improving bioprocesses and biotransformations. We optimize different complex proteolytic bioprocesses for better utilization of by-products following European standards in quality and in environment impact. We investigate the valorisation of by-products and residues, searching for the economic convenience of the company first. We conduct pilot tests to obtain improved formulations of active peptides and amino acids with potential applications in different industrial sectors: feed, biomedicine, plant, food, etc.
  
  APPLICATIONS IN THE DAIRY INDUSTRY
  
  1) Ripening of cheeses: Lipases are used to accelerate the ripening of blue cheeses. For the production milk rennet, renins and pepsins are used.
  
  2) The use of enzymes in pastry and bakery such as Amylases, beta-Glucanases, Hemicellulases, and Xylanases produce more sugars for the fermentation and improve the quality and taste of the bread and bakery products.
  
  3) Total Hydrolyzed Whey for functional foods. By total biohydrolysis of whey an hydrolysate is obtained with high content of essential amino acids suited for human nutrition. Exo and broad spectrum Endoproteasas are used.
  
  4) For a clarifying effect of fruit juices and vegetables using various enzymes: Hemicellulases, Pentosanases, Cellulases, Xylanases and Pectinases. To remove the bitter taste of grapefruit juice because of the citrus peel alpha-L-Rahmanosidase and beta-Glucosidase are used.
  
  APPLICATIONS IN THE PRODUCTION OF FEED
  
  Production of feed products highly digestible. This can be achieved with the addition of certain enzymes in the animal feed, such as Glucanases, Xylanases, Amylases and Phytases (better absorption of phosphate)
  
  1 .- Use of enzymes for the degradation/treatment of cererals. Among these enzymes are: Amylases, Xylanases, Gluconases and Cellulases, mainly from microbial source.
  
  2 .- Use of microbial proteases to hydrolyze proteins, to obtain highly valued amino acids and peptides.
  
  3 .- Degradation of phytate by using Phytase of bacterial origin.
  
  APPLICATIONS IN MEAT AND FISH INDUSTRIES
  
  1) For tender and tasty meats. By enzymatic treatment of certain meat cuts using papain, Endo and Exo Peptidases as well as Acid Proteases a more tender meat is obtained.
  
  2) total hydrolysate from meat for functional foods. By total biohydrolysis of meat and fish, an hydrolysate is obtained with high content of essential amino acids for human nutrition. Exo and broad spectrum Endoproteasas are used, as well as Collagenases.
  
  3) What to do with category 3 meat waste?
  The use of enzymes on of hard to degrade waste and residues (hooves, horns, hair, fur, etc.) from meat processing plants, produces free amino acids and bioactive peptides with important applications in phytosanitary. We use enzymes such as Collagenases, Pz-Peptidases, Keratinases and Subtilisin.
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O-891University of Granada / España 1299

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Aminopeptidasas como biomarcadores de daño renal

Diagnostic methods-Renal biomarkers, kidney damage, Fluorimetric detemination
- Descripción de la oferta tecnológica :
  
  La técnica consiste en la determinación fluorimétrica de la actividad aminopeptidasica en la orina. Esta técnica ha sido desarrollado por investigadores de la Universidad de Granada. Se trata de un método no invasivo, rápido y de bajo coste que puede detectar el daño renal en sus etapas iniciales. Puede ser útil en el diagnóstico y pronóstico de patologías con insuficiencia renal o pruebas de medicamentos. Se buscan empresas interesadas en el desarrollo y comercialización de un kit de diagnóstico.
  
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  The determination of these markers has many advantages over other markers of kidney damage, such as:
  
  - High specificity. These enzymes are very abundant in the renal tubules and their high molecular weight prevents that their presence in urine has a plasmatic origin.
  
  - High sensitivity. Their aminopeptidasic role promotes that urinary activities are greatly increased, even in the case of a slight renal damage.
  
  - The fluorimetric method of determination is fast, simple and inexpensive. Its sensitivity and reproducibility is greater than colorimetric methods. Antibodies are not needed, so its cost is much lower than
  immunological methods.
  
  - The urine sample needs no special treatment and it can be frozen until determination. Leer más
O-1044University Pablo de Olavide / España 1306

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Método para el cultivo y mantenimiento de células madre pluripotenciales y células progenitoras de mamíferos en una etapa no diferenciada

Stem Cells, parent cells, culture medium, cell growth, cells, biotechnological applications, biotehcnology, Biomedicine
- Descripción de la oferta tecnológica :
  
  La presente innovación describe un nuevo método para el cultivo y mantenimiento de células pluripotenciales y células progenitoras de mamíferos en una etapa no diferenciada, usando óxido nítrico. Este nuevo método hace que sea posible cultivar y mantener las células madre pluripotenciales y células de mamíferos matrices en una etapa no diferenciada mediante la adición de óxido nítrico para el cultivo. Las células pluripotenciales de mamífero madre pueden obtenerse a partir de tejidos adultos o de tejidos fetales, o pueden ser células madre embrionarias, incluidas las de embriones humanos.
  
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  New method for the cultivation and maintenance of pluripotential cells and of mammalian parent cells in a non-differentiated stage, using nitric oxide.
  The addition of nitric oxide can be performed by means of exogenous donors, directly into the culture medium in different concentrations and, optionally, mixed with other compounds, preferably proteins obtained from extracellular matrices, as a support for cell growth. Alternatively, the addition of nitric oxide is performed by means of endogenous production of nitric oxide, preferably by an over expression of the enzymes involved in the synthesis of nitric oxide, preferably the endothelial nitric oxide synthase. A specific manner of performing such endogenous production of nitric acid would be a transfection of the pluripotential mammalian stem cells with a plasmid inducing the over expression of the endothelial nitric oxide synthase. Leer más
O-1181Innovation Department - Hospital Clinic Barcelona / España 329

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Nueva prueba para el pronóstico de la leucemia linfocítica crónica (CLL)

Chronic Lymphocitic Leukemia, CLL, prognosis, biomarker, methylation, patient stratification
- Descripción de la oferta tecnológica :
  
  La presente invención tiene por objeto el desarrollo de una nueva prueba de diagnóstico en la LLC para una mejor estratificación de los pacientes en los grupos de pronóstico
  • Esta nueva herramienta es capaz de clasificar CLLS en 3 nuevos grupos pronósticos: tipo MBC, intermedio y tipo NBC, con sólo 5 biomarcadores epigenéticos
  • Después de 10 años necesitarán tratamiento sólo el 20% de los pacientes del grupo MBC, el 43% del grupo NBC y el 100% del grupo NBC.
  • Esta estratificación permitirá un mejor manejo de los pacientes, mejorar su calidad de vida y para racionalizar el gasto sanitario
  
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  The current classification of M-CLL (mutated) and U-CLL (unmutated) is not used in clinical protocols to decide upon patient treatment and follow-up. The possibility of a better diagnosis and prognosis of CLL would be very useful for the proper management of the patients.
  Follow-up checks could be done less frequently improving the quality of life of those patients that have a better prognosis, such as the MBC-like group.
  This test will allow to:
  - Improve the quality of life of CLL patients
  - Improve management strategies that are more adjusted to the biology of this disease
  - Reduce the health care costs Leer más
O-999Centro Tecnológico BIO-GLS (Universidad Autónoma de Barcelona) / España 1306

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Nuevo y preciso método de determinación de la biodegradabilidad aeróbica y anaeróbica de los residuos orgánicos sólidos utilizando BMP respirometría precisa y dinámica

waste, respirometry, Biogas, compost, digestate, stability, biodegradability,
- Descripción de la oferta tecnológica :
  
  Tenemos la posibilidad de realizar análisis de biodegradabilidad de los desechos sólidos orgánicos de diversos orígenes: residuos industriales y municipales. Podemos utilizar estas tecnologías para determinar el índice de respiración dinámica (biodegradabilidad aeróbica) o BMP para mejorar, evaluar o diseñar procesos de digestión anaerobia.
  
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  Both technologies are the most reliable and useful methodologies to measure the biodegradability and stability of all range of organic wastes. The dynamic aerobic respirometry differs from the typical tests, based on the self-heating of the sample, since it can monitor the whole biodegradation process and give as result the total oxygen consumption derived from the biodegradation of the sample, related with the biodegradable organic matter content and the consumption rate of oxygen, related with the biodegradability and stability. The biogas test are a simple and useful technique to determine the real potential production of biogas (or methane) when treating organic wastes through anaerobic digestion processes avoiding gross estimations from data bases Leer más
O-507BIOPOLIS, S.L. / España 3174

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Nuevo probiótico (Bifidobacterium longum) que inhibe la respuesta inflamatoria inducida por gliadinas en pacientes con enfermedad celíaca

Biotechnology, microorganism, probiotics, Bifidobacterium longum, coeliac disease, gluten
- Descripción de la oferta tecnológica :
  
  Una nueva cepa de la Bifidobacterium longum CECT 7347 ha sido demostrado como un probiótico eficaz en enfermedades celíacas. Esta cepa es capaz de reducir los riesgos y mejorar la salud y la calidad de vida de las personas con enfermedad celíaca y otros trastornos relacionados con la ingestión de gluten.
  
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  Efficient probiotic in coeliac diseases. This strain is capable to reduce the risks and improve the health and quality of life of individuals with coeliac disease and other disorders related to gluten ingestion. The strain is capable of taking up and hydrolysing the gluten peptides responsible for the disorders. This strain has immunomodulatory properties. The strain is also capable of inhibiting pathogenic bacteria.
  
  Gluten proteins (gliadins and analogous prolamins and glutenins) represent the main environmental factor that triggers coeliac disease and other related disorders. These proteins contain peptide sequences rich in proline and glutamine, making them more resistant to digestive enzymes than other proteins in the diet and,therefore, capable of remaining in the intestinal lumen. In genetically predisposed individuals, these peptides are responsible for an anomalous reaction that involves both the innate and the adaptive immune system and that, globally, lead to chronic inflammation of the intestinal mucosa, increased intraepithelial lymphocytes, crypt hyperplasia, and a progressive deterioration of intestinal villi including their total disappearance.
  
  The composition of the intestinal microbiota of celiac disease patients also presents an imbalance in relation to that of healthy control individuals, characterised by the predominance of proinflammatory bacteria and a reduced proportion and composition of lactic acid bacteria and bifidobacteria.
  
  A new strain of the Bifidobacterium longum (CECT 7347), its cellular components, secreted molecules and compounds resulting from its metabolism and any combinations thereof with each other and/or with other microorganisms or bioactive compounds, in the form of preparations were designed to reduce the risks and improve the health and quality of life of individuals with coeliac disease. Leer más
O-362PomBioTech GmbH / Alemania 1222

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Custom drug metabolite production via whole-cell biotransformation assays

Drug, metabolite, glucuronide, cytochrom P450, Biotechnology
- Descripción de la oferta tecnológica :
  
  PomBioTech has specialized on the biotechnological production of cytochrom P450 drug metabolites and glucuronides. Besides the production of metabolites our CRO activities include the generation of custom made fission yeast strains that are specifically tailored e.g. for protein production. In addition to these CRO activities, PomBioTech has a dedicated in-house R&D department which focuses on the development of new technology platform.
  
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  PomBioTechs offers the custom production of drug metabolites using a biotechnological approach. This service is of special interest for ADME-Tox and Pharmacokinetics departments of pharmaceutical companies that are engaged in drug development processes. PomBioTech possesses a comprehensive set of different human cytochromes P450, UDP-glucuronosyltransferases (UGT) and hydroxysteroid dehydrogenases (HSD) expressing fission yeast strains to meet the demands of our customers. Using these strains we are able to offer custom production of drug metabolites up to technical scale as well as inhibitor screening systems.
  
  In contrast to chemical processes, biotechnological approaches allow the use of specialized enzymes. These display their activity only on defined positions of a target molecule, even if from a chemical point of view the same reaction would be possible on other positions as well. With intricate target molecules with many possible reaction positions (like steroid hormones) enzymatic reactions therefore lead to significantly fewer unwanted side-products than chemical reactions. Because enzymatic reactions normally take place in living cells, they do not require the extreme reaction conditions (e.g. high pressure, high temperature, toxic auxiliary substances) that are typical for chemical reactions. Due to these attributes biotechnological operations in many cases are much more efficient and cost-saving than the corresponding chemical processes.
  
  Metabolite production is performed in a whole cell biotransformation assays using our patented recombinant fission yeast strains. Subsequently, the metabolite of interest is purified using chromatographic methods. Our clients can completely outsource their metabolite production into the hands of our highly qualified scientists and can focus on other important issues, helping you to save time and money.
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O-364PomBioTech GmbH / Alemania 1232

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Production of reference standards (e.g. drug metabolites) for mass spectrometry

Drug, metabolite, glucuronide, cytochrom P450, Biotechnology
- Descripción de la oferta tecnológica :
  
  PomBioTech has specialized on the biotechnological production of cytochrom P450 drug metabolites and glucuronides. Besides the production of metabolites our CRO activities include the generation of custom made fission yeast strains that are specifically tailored e.g. for protein production. In addition to these CRO activities, PomBioTech has a dedicated in-house R&D department which focuses on the development of new technology platform.
  
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  PomBioTech produces a range of labeled (13C- or deuterium) and unlabeled drug metabolite standards (e.g. Cytochrome P450 metabolites and glucuronides). These metabolites can be used as reference substrates for mass spectrometry (MS). These products are of special interest for ADME-Tox and Pharmacokinetics departments of pharmaceutical companies that are engaged in drug development processes as well as for academic institutions. PomBioTech possesses a comprehensive set of different human cytochromes P450, UDP-glucuronosyltransferases (UGT) and hydroxysteroid dehydrogenases (HSD) that are used for the production of cytochrom P450 reference metabolites as well as glucuronides. Metabolite production is performed in a whole cell biotransformation assays using our patented recombinant fission yeast strains. Subsequently, the metabolite of interest is purified using chromatographic methods.
  
  In contrast to chemical processes, biotechnological approaches allow the use of specialized enzymes. These display their activity only on defined positions of a target molecule, even if from a chemical point of view the same reaction would be possible on other positions as well. With intricate target molecules with many possible reaction positions (like steroid hormones) enzymatic reactions therefore lead to significantly fewer unwanted side-products than chemical reactions. Because enzymatic reactions normally take place in living cells, they do not require the extreme reaction conditions (e.g. high pressure, high temperature, toxic auxiliary substances) that are typical for chemical reactions. Due to these attributes biotechnological operations in many cases are much more efficient and cost-saving than the corresponding chemical processes.
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O-909University of Granada / España 962

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Nueva prueba para la determinación de la respuesta al tratamiento con 5-FU en pacientes con cáncer de colon o de mama

Protein-quinasa, PKR, Marker, 5-Fluoracil, breast cancer, Colon cancer
- Descripción de la oferta tecnológica :
  
  El ARN dependiente de la proteína-quinasa PKR se activa en respuesta a 5-FU, induciendo la detención de la síntesis de las proteínas celulares y, finalmente, produciendo la muerte de las células tumorales por apoptosis. Por lo tanto, PKR actúa como un supresor de tumores, y recientemente se ha demostrado que puede inducir la muerte celular en respuesta a 5-FU, incluso en ausencia de la conocida proteína supresora de tumores p53. Por lo tanto, se puede utilizar como un marcador celular clave para predecir la muerte de las células tumorales como resultado de la terapia con 5-FU.
  
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  The assays with cell lines and with samples of patients with cancer show that mutations in the sequence of the gene coding for PKR, or changes in the activity of this protein correspond with patients that do not respond to the treatment with 5-FU, neither to 5-FU combined with other drugs or cytokines, as the interferon alpha, which in general are more effective than the treatment with 5-FU alone. Therefore, the determination of either the sequence of the PKR protein, or the sequence of the pkr gene, or the activity of said protein, are exceptionally relevant data for evaluating the response to the 5-FU treatment, in particular in patients with colon and breast cancer.
  
  Other previous studies have tried to analyse the relation between the status of various enzymes involved in the DNA replication, as the thymidylate synthetase (TS), the dihydropyrimidine dehydrogenase (DPD), or the thymidine phosphorylase (TF), with the response to 5-FU. In most of the cases, the conclusion is not clear, and it has been proposed to analyse different markers to predict correctly the response to the chemotherapy.
  
  On the other hand, other studies have analysed the tumor suppressor protein p53 as a marker. However, it is known that more than 50% of the tumors have mutations or lack p53, which has an essential role in the apoptosis and in the control of the cell cycle. In these patients, it has been demonstrated that the presence of a functional PKR has a key role, as it is the only known alternative to p53 to be able to induce the cell death. Therefore, it is essential in these cases to determine the status of PKR in order to predict the effectiveness of 5-FU. Leer más
O-272University of Alicante / España 1073

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Novel method to fabricate highly selective sensors for different substances of interest

adhesives, dioxin, electrocoagulation, holographic, wastewater, hepatitis, electrodialysis
- Descripción de la oferta tecnológica :
  
  Novel method that allows highly selective electrode manufacture biometrics to detect any biochemical substance of interest, food or environmental. The method is based on the electro assisted deposit of molecularly imprinted silica layers on different electrodes. This allows a fast and efficient detection of the molecule of interest, independently of the other interfering. In addition, allows the regeneration of the electrode in a very simple way and lets its usage almost indefinitely.
  
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  The research group "Electro catalysis and Electrochemistry of Polymers", Department of Physical Chemistry at the University of Alicante has developed a novel method that allows highly selective electrode manufacture biometrics to detect any biochemical substance of interest, food or environmental. The method is based on the electro assisted deposit of molecularly imprinted silica layers on different electrodes. This allows a fast and efficient detection of the molecule of interest, independently of the other interfering. In addition, allows the regeneration of the electrode in a very simple way and lets its usage almost indefinitely.
  
  Market applications
  
  The biometric electrodes are used for highly selective detection of any substances of biochemical, nutritional or environmental interest, among others.
  
  1) Biomedical Sector:
  - Hormones: Melatonin, serotonin, adrenaline / epinephrine, noradrenaline / norepinephrine, angiotensin, vasopressin, calcitonin, erythropoietin, glucagon, insulin, growth hormone, oxytocin, histamine, cortisol, testosterone, progesterone
  - Neurotransmitters: dopamine, acetylcholine, endorphin, taurine, gaba ...
  - Sugars: glucose, galactose, fructose, sucrose, lactose, maltose ...
  - Aminoácidos: glutamato, aspartato, glicina…
  - Proteins
  - Enzymes
  - Antigens
  - Cholesterol
  - Uric Acid
  
  2) Food control
  - Resveratrol
  - Cytotoxins
  - Alkaloids
  - Pesticides
  - Vitamins
  
  3) Environmental control and defense
  - Pollutants
  - Pathogens
  - Explosives
  
  4) Others
  In general, any organic molecule or biologically active metabolite can be analyzed by electrochemical methods
  
  Innovative aspects
  
  The biometrical electrode manufacturing method is based on a electro assisted method of molecularly imprinted silica layers on different electrodes. With this new procedure, we obtain uniform and consistent layers of silica that allow highly selective detection of any biochemical substance of interest, food or environmental when these electrodes are used as amperometric, voltammetric, impedimetric and potentiometric sensors.
  Main advantatges of the technology
  
  The main advantage of the electro assisted deposit respect to conventional methods of thin film deposition (spin-coating or dip-coating), lies in the control of consistency and porosity of the layers. Due to the prevention of uncontrolled pore formation, avoids the indiscriminate passage of species from the solution to the electrode surface, reducing the interference in the detection of the analyte of interest.
  
  It has a high specificity and affinity for the molecule of interest.
  
  High control on the deposition of silica when is done by electro assisted mode. The possibility of varying the thickness of the silica layer and layer morphology allows for a highly consistent and reproducible layer.
  
  Electro assisted deposit method is capable of "self-healing", i.e. prevents the formation of holes in the assisted layer that interfere with the detection of the molecule of interest.
  
  With continued use, the sensor loses its effectiveness by the collapse of the pores with the species to be determined. In this case, the regeneration process is very simple: just repeat the procedure for removing the template molecule to be performed after the gel layer (electrochemical extraction or cleaning solvents). Thus, the pores of the sensing phase are released for use again. Leer más
O-296Laser Consult Ltd. / Hungr 1183

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Carrier materials for mosquito-larvae killing pesticides

technology transfer, IP, technology offer, technology request, patent
- Descripción de la oferta tecnológica :
  
  Novel way for the production of carrier materials for mosquito-larvae killing pesticides.
  
  A special kind of the formulation given in the present invention (which is possible to be manufactured upon request) is a multilayer carrier/larvicide composite granulate where the grains have an inner solid nucleus and may be built up from one or more outer layers which have larger density than the density of water. The thickness, type and amount of the outer layers control the dissolution/peeling off time. After dissolution/peeling of some of the outer layers, the density of the inner nucleus becomes dominant and the granulates start floating. The release of the larvicides start and the extermination of the mosquito larva begins.
  
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  Aspectos nuevos e innovadores
  
  Our partner, a Hungarian Institute has developed a novel way for the production of carrier materials for mosquito-larvae killing pesticides. They are interested in a license agreement for the production of pesticide carrier substrate or selling of production equipments or the carrier material itself.
  
  Innovation of the products:
  
  The subject of the present invention are carrier materials for mosquito-larvae killing pesticides (carrier composites). Numerous insecticide preparations have already been developed for exterminating the adult mosquitoes. However the resistency and extermination of other useful insects are problematic and there are non-avoidable side effects.
  
  Since the mosquito-larvae mainly live at water surface their extermination can be limited to the living area of mosquito larva. Having realized this fact a lot of larvicide have been developed that used mineral and vegetable oil derivatives to float on the water surface. A common disadvantage of these materials is the environmental damage.
  
  Taking into consideration the environmental damage, some selective biological larvicides have also been developed. Since the mosquito larva live on water surface, some floating carriers have also been developed to carry these biological larvidices. The main disadvantage of these carriers is their inability to decompose in the environment due to their artificial polymer content.
  
  The mechanical strength of the low-density carriers is generally low due to the presence of large amount of air pores. Therefore, their spray from aircrafts is not useful due to their low level of stability towards mechanical impacts.
  
  Presently no suitable carrier is available for biological or chemical larvicides which would ensure all of the required abilities such as floating/controlled time floating on water surface, controlled release of larvacide, environmental friendly with selective components, controlled sinking and decomposition time, good storage stability and mechanical strength for homogeneous spraying from aircrafts. Therefore our partner has developed some new carrier materials for mosquito-larvae killing pesticides (carrier composites) and mosquito-larvae killing products (larvicide composites) which fulfil all of the above mentioned requirements and have also developed some appropriate procedure for their manufacture.
  
  A special kind of the formulation given in the present invention (which is possible to be manufactured upon request) is a multilayer carrier/larvicide composite granulate where the grains have an inner solid nucleus and may be built up from one or more outer layers which have larger density than the density of water. The thickness, type and amount of the outer layers control the dissolution/peeling off time. After dissolution/peeling of some of the outer layers, the density of the inner nucleus becomes dominant and the granulates start floating. The release of the larvicides start and the extermination of the mosquito larva begins.
  
  It gives a chance to perform the spreading of larva killing granules before vegetation. The granules are sunk in the water after spreading (before vegetation grows). Later (after large growth of vegetation when direct spreading is not possible) the outer layer of the granules is peeled off and these are lifted to the surface, the larvicide composites release the larvicide.
  
  Advantages of the technology:
  
  - The special low-density highly porous carrier material can absorb a lot of liquid (ca. double of its weight), namely the fermentation liquor containing larvicides
  - The air-drying in mild conditions gives a stabilized encapsulated biological mosquito killing agent without liophylization step
  - The chemical composition of the granules gives an appropriate medium to stabilize and enhance the effectivity of the enzymes of larvicides
  
  Advantages of the product:
  
  • Low-density and sizes
  • Cheap air-spreadability
  • High surface density on water
  • Controlled larvicide capacity
  • Floatability and time-dependent sinkability
  • Low production costs
  • Selectivity for blood-sucking mosquitoes
  • Combinability with other active ingredients
  • No environmental pollution
  • Long storage ability
  • Combination with attractants for female mosquitoes to put larva in a treated area
  
  Potential areas of use:
  Typical application areas:
  - environment protection
  - agriculture
  - tourism
  - war against malaria, dengi and mosquito-spreaded diseases
  Typical customers:
  - municipalities
  - government (E.g. India) Leer más

5TH NEW PRODUCT DEVELOPMENT AND INNOVATION MANAGEMENT

3rd Annual Alliance Management for Open Innovation in Pharma

XXIV ISPIM Conference, 16-19 June 2013, Helsinki, Finland: Innovating in Global Markets:

The 6th ISPIM Innovation Symposium – Innovation in the Asian Century

Innovación en Enzymes : Oportunidades ... | Ofertas

Innovación en Enzymes : Oportunidades ... | Ofertas

microencapsulation of enzymes, food enzymes, cheese maturation, cheese ripening, cheese production, cheese, encapsulated enzymes, Dairy, food technology, food technologists, food ingredients

Biotechnology, Industrial Biohydrolysis, Biocatalysts Processes, Biomedicine, Molecular Diagnostics, Recombinant Enzymes

Zurko Research offers a quality service in the cloning, expression and purification of proteins on demand. Applications in dairy, meat and fish industry as well as in the feed production

Diagnostic methods-Renal biomarkers, kidney damage, Fluorimetric detemination

Stem Cells, parent cells, culture medium, cell growth, cells, biotechnological applications, biotehcnology, Biomedicine

Chronic Lymphocitic Leukemia, CLL, prognosis, biomarker, methylation, patient stratification

waste, respirometry, Biogas, compost, digestate, stability, biodegradability,

Biotechnology, microorganism, probiotics, Bifidobacterium longum, coeliac disease, gluten

Drug, metabolite, glucuronide, cytochrom P450, Biotechnology

Drug, metabolite, glucuronide, cytochrom P450, Biotechnology

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adhesives, dioxin, electrocoagulation, holographic, wastewater, hepatitis, electrodialysis

technology transfer, IP, technology offer, technology request, patent

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